Ann Kananu was thrown into national limelight after former Nairobi Governor Mike Mbuvi Sonko on January 6, 2020 nominated her as his deputy governor.

Prior to her nomination, Ms Kananu maintained a low profile as a senior county official and was little known in Nairobi leave alone nationally.

At the time, she was the Nairobi County Chief Officer for Disaster Management and Coordination, a position she held for the last two years.
However, her nomination to the deputy governor position hit a hurdle after the High Court barred her vetting by the County Assembly pending the hearing and determination of petitions filed in court.